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badrilla生物技術公司成立于2003年,總部位于利英國。badrilla使分配特殊的單克隆抗體和多克隆抗體的蛋白質和磷酸化蛋白的目標心血管。badrilla生命科學試劑公司專注于研究工具為心血管疾病的研究,尤其是對心肌興奮收縮偶聯。badrilla為工業界和學術界的研究實驗室制造和驗證抗體的心臟蛋白和磷酸蛋白。
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Description: A fully validated, highly specific polyclonal anti-serum to Serine-16 phosphorylated forms of phospholamban (PLB PS-16)
Background: Phospholamban (PLB/PLN) is a small transmembrane protein which plays an important role in controlling the activity of the sarcoplasmic reticulum ATPase (SERCA2a) of cardiac muscle during calcium sequestration. Phospholamban is phosphorylated on separate amino acid residues by cAMP-dependent, and cGMP-dependent (Ser-16) and Ca2+/CaM-dependent (Thr-17) protein kinases in response to β-adrenergic stimulation. Akt has also been shown to phosphorylate Thr-17. The result is an increased calcium pump activity which reduces the time course of the calcium transient, increases the calcium load in the sarcoplasmic reticulum, and consequently, produces a larger calcium transient at the next action potential. However, alteration in this homeostatic interaction has been shown to result in heart failure
Unit Volume: 20 ul
Tested Applications: Western Blot (1:5000 dilution), ELISA
Antibody Form: Lyophilised Rabbit anti-serum (IgG).
Species Recognition: All mammalian species, when phosphorylated on Ser-16.
Full Publication list: 114 papers
Storage | Lyophilised: 4 °C Reconstituted:-80 °C |
---|---|
Epitope/Isoform Alignment | N/A |
Epitope/Species Alignment | Ep/Sp Alignment |
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