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蛋白激酶C(PKC)家族成員在細胞生長分化、基因表達、激素分泌和膜功能等多種細胞功能中發揮著重要的調控作用。PKCs初被鑒定為絲氨酸/蘇氨酸蛋白激酶,其活性依賴于鈣和磷脂。甘油二酯(DAG)和促腫瘤佛波酯與PKC結合并激活PKC。PKC至少可分為兩大類,包括傳統的(c)PKC亞型(α,βI,βII和γ)和新的(n)PKC亞型(δ,ε,ζ,η,θ,λ/ι,μ和ν)。每個PKC亞型在不同組織中的表達模式不同,PKC家族成員在其輔因子依賴性上表現出明顯的差異。例如,PKCδ和ε的激酶活性與Ca2+無關。另一方面,大多數PKC成員具有佛波酯結合活性和激酶活性。
種屬 | 基因名稱 | 基因ID | 染色質位置 | 亞型(MRNA)即位號碼 | 蛋白質即位號碼 | OMIM™ 號碼 |
---|---|---|---|---|---|---|
Human | PRKCA | 5578 | 17q24.2 | XM_017024836, XM_017024837, XM_017024838, XM_017024839, XM_017024840, XM_017024841, NM_002737 | P17252 | 176960 |
Mouse | Prkca | 18750 | 11 E1 | NM_011101 | P20444 | N/A |
全長 PKC 蛋白序列,免疫原序列已高亮:
MADVFPGNDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNMELRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNPQFVHPILQSAV
貨號 | 品名 | 規格 | 應用 | 反應種屬 | 價格 |
Sc-268x | GATA-3 Mouse McAb | 0.1ml | WB, IP, IF 和 IHC(P) | mouse, rat, human,avian | 0 |
sc-9081x | Oct-3/4 Rabbit PcAb | 0.1ml | WB | mouse, rat, human | 0 |
sc-8396 | cyclin D1 (A-12) Mouse McAb | 0.1ml | WB, IP, IF, IHC(P), FCM , ELISA | mouse, rat ,human | 0 |
sc-7244x | GATA-6 | 0.1ml | WB | mouse, rat, human | 0 |
sc-516102 | m-IgGκ BP-HRP(recombinant protein) | 25ul | WB,IHC | mouse | 0 |
sc-515536 | TBX5 (A-6)Mouse McAb | 50ul | WB, IP, IF 和 ELISA | human | 0 |
sc-12756 | Mcl-1(22) Mouse McAb | 50ul | WB, IP 和 ELISA, | human | 0 |
sc-9961 | SAP97(2D11)Mouse McAb | 50ul | WB, IP, IF , IHC(P) | mouse, rat, human,canine | 0 |
sc-136958 | SnoN (B-3) Mouse McAb | 50ul | WB, IP, IF, IHC(P), ELISA | mouse, rat, human | 0 |
sc-126 | p53(DO-1)Mouse McAb | 50ul | WB, IP, IF, IHC(P) , FCM | mouse, rat, human | 0 |
sc-376830 | YAP(G-6)Mouse McAb | 50ul | WB, IP, IF, IHC(P) , ELISA | mouse, rat, human | 0 |
sc-365504 | c-Kit(E-3) | 50ul | WB, IP, IF , ELISA | mouse, rat, human | 0 |
sc-2003 | Protein A/G PLUS-Agarose | 2ml | 0 | ||
sc-362188 | TBS | 1L | 0 | ||
sc-362300 | Phosphate Buffered Saline: powder for 100 ml of 10X | ea | 0 | ||
sc-362190 | Tris Buffered Saline with Tween 20: powder for 100 ml of 10X | ea | 0 |
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