Integral Molecular是一家研究驅(qū)動(dòng)的生物技術(shù)公司,為未被開發(fā)的膜蛋白靶標(biāo)(包括GPCR,離子通道,轉(zhuǎn)運(yùn)蛋白和病毒包膜)創(chuàng)造創(chuàng)新技術(shù)和治療性抗體。整合膜蛋白包括關(guān)鍵的治療靶,但由于其結(jié)構(gòu)復(fù)雜性和不能在構(gòu)象完整狀態(tài)下從脂質(zhì)膜中除去而難以研究。在Integral Molecular,我們開發(fā)創(chuàng)新技術(shù)和產(chǎn)品,以滿足這些苛刻但重要的目標(biāo)。
病毒樣顆粒上的高濃度膜蛋白,用于藥物和抗體的發(fā)現(xiàn)。
為什么我需要Lipoparticles用于抗體免疫和篩查?
脂質(zhì)顆粒是病毒樣顆粒(VLP),其天然構(gòu)象含有高濃度的特異性膜蛋白。脂質(zhì)顆粒直接從細(xì)胞表面捕獲構(gòu)象完整的膜蛋白,使得這些復(fù)合蛋白能夠作為可溶性蛋白進(jìn)行操作,用于抗體免疫和篩選。
Lipoparticle
定制脂質(zhì)顆粒
定制脂質(zhì)顆粒以包含任何選擇的膜蛋白。使用質(zhì)量控制指標(biāo)評(píng)估每批脂質(zhì)顆粒,以確保均一性,純度和目標(biāo)蛋白質(zhì)完整性。數(shù)百種膜蛋白靶標(biāo)已成功摻入脂質(zhì)顆粒中。對(duì)于特定應(yīng)用,可以用生物素或熒光修飾脂質(zhì)顆粒。
ReadyReceptor Lipoparticles
預(yù)先驗(yàn)證的Lipoparticles含有優(yōu)化的,高度表達(dá)的膜蛋白,可用于快速遞送。ReadyReceptor Lipoparticles使用Custom Lipoparticle生產(chǎn)中使用的所有嚴(yán)格質(zhì)量指標(biāo)生成和驗(yàn)證。
蛋GPCR
Receptor | Description | Catalog No. |
A2AR | Alpha Adrenergic | RR-0910 |
B2AR | Beta Andrenergic | RR-0574 |
CR | Complement | RR-0362 |
CCR1 | Chemokine | RR-0968 |
CCR2b | Chemokine | RR-0125 |
hCCR5 | Chemokine | RR-0190 |
mCCR5 | Chemokine | RR-0835 |
rhCCR5 | Chemokine | RR-0895 |
CCR6 | Chemokine | RR-0822 |
CCR10 | Chemokine | RR-0193 |
CXCR2 | Chemokine | RR-0943 |
CXCR3 | Chemokine | RR-0132 |
CXCR4 | Chemokine | RR-0830 |
CXCR7 | Chemokine | RR-0656 |
mCXCR4 | Chemokine | RR-2194 |
GLP-1R | Glucagon-like peptide-1 Receptor | RR-1090 |
GCGR | Glucagon Receptor | RR-0999 |
GAL1 Receptor | Neuropeptide Receptor | RR-1067 |
5-HT2C | Serotonin Receptor | RR-1498 |
FZD4 | Wnt Pathway | RR-1302 |
Ion Channel
Receptor | Description | Catalog No. |
HV1 | Voltage Gated H+ | RR-0678 |
TRPC4 | Nonspecific Cation Channel | RR-1054 |
TRPM4 | Nonspecific Cation Channel | RR-1333 |
K2P1.1 | Potassium Channel | RR-1225 |
K2P4.1 | Potassium Channel | RR-1331 |
P2X2 | ATP Purinoceptor | RR-1181 |
RTK
Receptor | Description | Catalog No. |
ALK2 | Activin Receptor | RR-0850 |
1-TM
Receptor | Description | Catalog No. |
ACVR1 | Activin Receptor, Type 1 | RR-0850 |
CD19 | B-Cell Activation | RR-0553 |
CD27 | B-Cell Activation | RR-0655 |
DC-SIGN | Lectin | RR-0057 |
DC-SIGNR | Lectin | RR-0056 |
LRP6 | Wnt Pathway | RR-0853 |
hTL1A | TNF Ligand | RR-0819 |
mTL1A | TNF Ligand | RR-0817 |
DR5 | TNF-family Receptor | RR-0818 |
ST2L | IL-1 Receptor Family | RR-0653 |
4-TM
Receptor | Description | Catalog No. |
CD81 | Hepatitis C Attachment | RR-0341 |
CD20 | B-Cell Activation | RR-1179 |
Claudin-1 | Tight Junction | RR-0825 |
Claudin-3 | Tight Junction | RR-0733 |
Claudin-4 | Tight Junction | RR-0686 |
Viral Protein
Receptor | Description | Catalog No. |
RSV-F | Respiratory Syncytial Virus | RR-0891 |
Influenza M2 A/Udorn/307/1972 | Ion Channel | RR-0929 |
Influenza M2 A/HK/156/1997 | Ion Channel | RR-0179 |
Chikungunya Virus | Viral Envelope | RR-0945 |
Ross River Virus | Viral Envelope | RR-1136 |
Transporter
Receptor | Description | Catalog No. |
GLUT1 | Glucose Transporter | RR-0777 |
Sample Kits
Lipoparticle sample kits containing CXCR4, CCR5 or CD20 are available for overnight delivery to enable application optimization and small-scale testing.
樣品套件
含有CXCR4,CCR5或CD20的Lipoparticle樣品試劑盒可用于隔夜輸送,以實(shí)現(xiàn)應(yīng)用優(yōu)化和小規(guī)模測(cè)試。
Sample Kit | Class | Cat. No | Size |
CXCR4 | GPCR | LEV-101, LEV-101B | 400 U |
CCR5 | GPCR | LEV-102, LEV-102B | 400 U |
CD20 | GPCR | LEV-103, LEV-103B | 400 U |
脂質(zhì)顆粒可以用(B)生物素或(F)熒光修飾。
上海起發(fā)實(shí)驗(yàn)試劑有限公司是實(shí)驗(yàn)試劑一站式采購(gòu)服務(wù)商
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