尿激酶型纖溶酶原激活物(Urokinase type Plasminogen Activator (uPA) ),uPA是一種絲氨酸蛋白水解酶。小鼠uPA基因位于第10條染色體長臂上,其長度為6.5KD,由11個外顯子構成,可轉錄成24KB的成熟的mRNA,初始翻譯產物為前尿激酶原(含431個氨基酸殘基),除去20個氨基酸殘基的信號肽后即為細胞分泌的尿激酶原(pro-uPA),在158LYs位處劈裂,則成為由二硫鍵連結的雙鏈活性型結構,即20×103的A鏈和34×103的B鏈。C端的A鏈包括一個Kringle區和表皮生長因子(EGF)功能區,表皮生長因子功能區能介導與特異的受體結合,去掉此功能區,其仍具有激活纖溶酶原作用,,但卻無與受體結合的能力。C端的B鏈有絲氨酸蛋白酶功能區,為uPA的活性中心。uPA的合成與分泌受諸多因素影響,如原癌基因V-Src、Ras、細胞因子TNF、INF、IL-1、TGF-β、IGF-1、FGF、基質金屬蛋白酶等。一般說來,uPA主要在生理、病理條件下與細胞分化、遷移、組織重建、細胞周圍基質降解有關。
尿激酶型纖溶酶原激活物(Urokinase type Plasminogen Activator (uPA) ),蛋白
貨號 | 品名 | 包裝 | 價格 | 品牌 |
ADG108 | Urokinase-Receptor (uPAR), human, rec | 200 µg | 9725 | American Diagnostica Inc |
107 | urokinase, human, single-chain (scuPA), frozen solution, dry-ice shipment | 25 µg | 6900 | American Diagnostica Inc |
ADG146NL | urokinase, human, amino terminal fragment (uPA-ATF), frozen solution, dry-ice shipment | 1 mg | 86375 | American Diagnostica Inc |
ADG146N | urokinase, human, amino terminal fragment (uPA-ATF), frozen solution, dry-ice shipment | 0.1 mg | 15500 | American Diagnostica Inc |
EZ005C | Urokinase type Plasminogen Activator (uPA) | 1 x 100,000 units | 4710 | hyphen biomed |
EZ005B | Urokinase type Plasminogen Activator (uPA) | 1 x 10,000 units | 1035 | hyphen biomed |
EZ00 | Urokinase type Plasminogen Activator (uPA) | 1 x 1,000 units | 465 | hyphen biomed |
ADG125N | Urokinase (uPA), human, recombinant, LMW, frozen solution, dry-ice shipment | 100 µg | 9725 | American Diagnostica Inc |
ADG102 | Urokinase (uPA), human, HMW | 250,000 IU | 詢價 | American Diagnostica Inc |
ADG100 | Urokinase (uPA), human, HMW | 10,000 IU | 5000 | American Diagnostica Inc |
128 | urokinase (uPA), human, HMW | 100,000 IU | 13452 | American Diagnostica Inc |
ADG244FN | SPECTROFLUOR® uPA | 10 µmole | 1850 | American Diagnostica Inc |
尿激酶型纖溶酶原激活物(Urokinase type Plasminogen Activator (uPA) )抗體
貨號 | 品名 | 包裝 | 價格 | 品牌 |
11651-05021 | Urokinase (uPA), anti-human | 150 ug | 2800 | AssayPro |
11651-05011 | Urokinase (uPA), anti-human | 150 ug | 2320 | AssayPro |
12172-05021 | uPA, anti-rat | 150 ug | 2800 | AssayPro |
12172-05011 | uPA, anti-rat | 150 ug | 2320 | AssayPro |
TC42000 | u-PA purified protein, lyo. 125 µg | RUO | 3941.28 | Technoclone |
TC31014 | Polyclonal anti u-PA antibody (rabbit)1 mg | RUO | 2650.98 | Technoclone |
TC31015 | Polyclonal anti u-PA antibody (rabbit) 5 mg | RUO | 4128.96 | Technoclone |
ADG3471 | murine MAb against uPA-ATF (aa 17-34) | 250 µg | 3950 | American Diagnostica Inc |
ADG3689 | murine MAb against uPA b-chain, affinity purified | 250 µg | 4475 | American Diagnostica Inc |
TC21063 | Monoclonal anti u-PA antibody 4UK | RUO | 4715.46 | Technoclone |
12171-05021 | ATF-uPA, anti-mouse | 150 ug | 2800 | AssayPro |
12171-05011 | ATF-uPA, anti-mouse | 150 ug | 2320 | AssayPro |
11661-05021 | ATF uPA, anti-human | 150 ug | 2800 | AssayPro |
11661-05011 | ATF uPA, anti-human | 150 ug | 2320 | AssayPro |
尿激酶型纖溶酶原激活物(Urokinase type Plasminogen Activator (uPA) )試劑盒
貨號 | 品名 | 包裝 | 價格 | 品牌 |
RK018A | ZYMUTEST uPA-PAI-1 complexes | Kit of 96 tests | 7800 | hyphen biomed |
RK013A | ZYMUTEST uPA Antigen | Kit of 96 tests | 7290 | hyphen biomed |
TC12010 | u-PA ELISA Kit 96 T. | RUO | 9196.32 | Technoclone |
TC16010 | u-PA Combi Actibind ELISA Kit 96 T. | RUO | 10603.92 | Technoclone |
894 | IMUBIND® uPA ELISA | 96 microwell plate | 10704 | American Diagnostica Inc |
EU1001-1 | Human Urokinase (uPA) ELISA Kit | 96 well plate | 4760 | AssayPro |
CU1001b | Human Urokinase (uPA) Chromogenic Activity Assay Kit (Indirect Assay) | 96 well plate | 6930 | AssayPro |
CU1001a | Human Urokinase (uPA) Chromogenic Activity Assay Kit (Direct Assay) | 96 well plate | 5530 | AssayPro |
899 | FEMLE™ uPA/PAI-1 ELISA, - CE | 2x96 microwell plates | 詢價 | American Diagnostica Inc |
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